Hypoxia inducible factor signaling and experimental persistent pulmonary hypertension of the newborn

Hypoxia inducible factor signaling and experimental persistent pulmonary hypertension of the newborn

BACKGROUND Mitochondrial reactive oxygen species (ROS) levels and nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) activity are increased in a lamb model of persistent pulmonary hypertension of the newborn (PPHN). These events can trigger hypoxia inducible factor (HIF) signaling in response to hypoxia, which has been shown to contribute to pulmonary vascular remodeling in r...

Prevalence of Persistent Pulmonary Hypertension of the Newborn and Associated Factors in Term Neonates Born in Southeast of Iran, 2020

 Background and purpose: Infants with persistent pulmonary hypertension (PPHN) are readmitted to hospital three times more than other infants or die after discharge. The disease imposes a high cost on families and health systems. In this study, for the first time, the prevalence of PPHN and associated factors were investigated in mature neonates born in southeast of Iran. Materials and methods...

Persistent Pulmonary Hypertension of the Newborn

Introduction: Persistent pulmonary hypertension of the newborn (PPHN) was first described by Gersony et al 1 of persistence of the fetal circulation in 1969. It is a clinical syndrome characterized by respiratory distress, hypoxemia, elevated pulmonary vascular resistance and a right to left shunting of venous blood across the foramen ovale and/or ductus arteriosus. The etiology of PPHN is not ...

Persistent Pulmonary Hypertension of the Newborn (pphn)

Expression of hypoxia-inducible factor-1α, endothelin-1 and adrenomedullin in newborn rats with hypoxia-induced pulmonary hypertension

Hypoxia-inducible factor (HIF)-1α is associated with hypoxia-induced pulmonary hypertension (HPH) in adults. In the present study, the expression levels of HIF-1α, endothelin (ET)-1 and adrenomedullin (ADM) were analyzed during HPH in neonates. In total, 96 newborn rats were subjected to hypoxia or normoxia for 3, 5, 7, 10, 14 or 21 days (n=8 per subgroup). HIF-1α, ET-1 and ADM expression level...